orologio en CB01 OFFICIAL. Three lifelong best friends known as “The Supremes” share the unbreakable bonds of sisterhood from decades of weathering life’s storms. Through the joys and sorrows of life, marriage and children, happiness and blues, love and loss, new shades of heartbreak and illness threaten to stir up the past when the trio sees their bond put to the test as they face their most challenging times yet.